• Participants (male or non-pregnant female) must be ≥ 18 years of age on the day of signing the informed consent.

• Participants with stage IV colon or rectal adenocarcinoma with resectable liver-dominant metastases and candidate to neoadjuvant FOLFOX followed by partial hepatectomy.

• Participants may have had resection of their primary colon or rectal adenocarcinoma in the past or will have their primary cancer resected at the same time as the liver metastases resection or after liver metastases resection.

• Participants must not have received prior chemotherapy for metastatic disease. Prior adjuvant chemotherapy and radiotherapy following resection of primary tumor is acceptable if completed at least 12 months prior to trial enrolment.

• For multiple liver metastases, participants may undergo liver metastases needle-ablation of some metastases combined with surgical resection of others, as long as at least one metastasis is surgically resected.

• Participants with at least one measurable lesion according to RECIST 1.1.

• Participants must have a liver metastasis amenable for biopsy with no contraindication for biopsy.

• Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2.

• Participants must have recovered from the toxic effects resulting from the most recent cancer treatment to Grade 1 or less. If the participants underwent major surgery, they must have recovered from the complications and/or toxicity.

⁃ Participants must have a life expectancy of at least 3 months.

⁃ Participants must have adequate organ and immune function

⁃ Female participants of childbearing potential must have a negative serum pregnancy test within 72 hours prior to the first dose of trial treatment.

⁃ Participants (both male and female) of reproductive potential must be willing to practice highly effective methods of contraception throughout the trial and for up to 90 days after the last dose of trial medication. Abstinence is acceptable if this is the participant's usual lifestyle.

⁃ Female participants are not considered of childbearing potential if they have a history of surgical sterility or evidence of post-menopausal status defined as any of the following:

⁃ i. ≥ 45 years of age and has not had menses for more than 2 years

⁃ ii. Amenorrheic for less than 2 years without hysterectomy and oophorectomy and a follicle stimulating hormone (FSH) value in the postmenopausal range at screening

⁃ iii. Post hysterectomy, oophorectomy, or tubal ligation. Documented hysterectomy or oophorectomy must be confirmed with medical records of the actual procedure or by ultrasound. Tubal ligation must be confirmed with medical records of the actual procedure.

⁃ Participants must understand and be able and willing and likely to fully comply with the trial procedures, including scheduled follow-up, and restrictions.

⁃ Participants must have given written personally signed and dated informed consent to participate in the trial in accordance with the International Conference on Harmonization (ICH) Good Clinical Practice (GCP) Guidelines, before completing any trial related procedures.